Apovincaminic Acid Hydrochloride Salt

Name	Apovincaminic Acid Hydrochloride Salt
Synonyms	Vinpocetine Carboxylic Acid HCl Apovincaminic Acid Hydrochloride Salt ApovincaMinic Acid Hydrochloride Salt Vinpocetine Carboxylic Acid HCl (Apovincaminic Acid HCl)
CAS	72296-47-0

Molecular Formula	C20H23ClN2O2
Molar Mass	358.87
Melting Point	>236°C (dec.)
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
Appearance	Solid
Color	White
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere

biological activity	Apovincaminic acid hydrate salt is Vinpocetine (VP) A major active metabolite that is orally active and can cross the blood-brain barrier. Apovincaminic acid hydrate salt has a neuroprotective effect.
Animal Model:	Male Harlan‐Wistar rats (300-400 g) are injected NMDA
Dosage:	10 mg/kg
Administration:	I.p. twice daily for 4 days
Result:	Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation.

Last Update：2024-04-09 21:11:58